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We studied the effect of non-rheumatic mitral stenosis (MS) on long-term prognosis after mitral valve replacement (MVR). A retrospective analysis of 219 patients with non-rheumatic MS who underwent MVR between 1993 and 2005 was performed. Patients were divided into two groups according to the presence (n = 66) or absence (n = 153) of MS. Univariate and multivariate analyses were performed to evaluate the impact of MS on mortality, morbidity, and clinical status after MVR. Patients with MS had a higher incidence of atrial fibrillation (p = 0.012), and required a higher rate of intraoperative transfusion (p = 0.013). Overall, the 30-day (5.9% vs. 1.2%, p = 0.024), 30-day to 1-year (10.1% vs. 1.7%, p = 0.021), and in-hospital (12.7% vs. 2.9%, p = 0.022) mortalities were higher in patients with MS, although the postoperative duration of hospitalization was not significantly longer (p = 0.14). The mitral valve replacement surgery-related morbidities were not significantly different between the two groups. However, the 5- 0b46394aab